Gefinancierde onderzoeksprojecten
Zoeken in gefinancierde projecten
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De Maag Lever Darm Stichting wil maag-, darm- en leverziekten helpen voorkomen en bestrijden en de kwaliteit van leven van patiënten verbeteren. Om dit doel te bereiken kunnen Nederlandse onderzoekers één keer per jaar subsidie aanvragen bij de Maag Lever Darm Stichting.
Hier kunt u meer lezen over de onderzoeksprojecten waar afgelopen jaren subsidie aan verleend is. De omschrijvingen zijn in het Engels.
Overzicht gefinancierde projecten
Mond
Slokdarm
- Barrett-slokdarm
- A prospective study on the intake of meat ens heme-iron, nitrite and nitrosamines as risk factors for adenocarcinoma of esophagus (EAC) and gastric cardia (GCC), esophageal squamous cell carcinoma (ESCC), and Barrett's esophagus (BE)
- SUrveillance vs. RadioFrequency ablation for the prevention of early neoplasia in Barrett's esophagus patients with low grade intra-epithelial neoplasia: The SURF study
- Reflux bij baby's
- Position control therapy in infant gastro-esophageal reflux disease: A randomized sham-therapy controlled clinical trial
- Slokdarmafsluiting
- Exploring the causative role of MYCN in esophageal atresias
- Slokdarmkanker
- A prospective study on the intake of meat ens heme-iron, nitrite and nitrosamines as risk factors for adenocarcinoma of esophagus (EAC) and gastric cardia (GCC), esophageal squamous cell carcinoma (ESCC), and Barrett's esophagus (BE)
- Evaluation of dendritic cell immunotherapy and curcumin as a combinatorial therapy for treating oesophageal adenocarcinoma
Maag
Lever
- Galstuwing
- Generation and characterization of mouse models with a predisposition to cholestatic liver disease
- Role of FGF19 in adaptive changes in the liver of patients with cholestatic liver disease
- The role of the intestinal farnesoid X-receptor FXR in cholestatic liver disease and NASH
- Vitamin A deficiency strongly aggravates liver damage during obstructive cholestasis: molecular mechanisms and implications for therapy
- Hepatitis C
- The cost-effectiveness of Problem Solving Therapy (PST) in hepatitis C patients
- Kanker in de lever
- Curbing c-Myc induced hepatocarcinogenesis through inhibition of PI-3-kinase
- Levercirrose
- Curbing c-Myc induced hepatocarcinogenesis through inhibition of PI-3-kinase
- Reduction of liver fibrosis by inhibition of insulin-like growth factor (IGF-1) binding protein-5
- Reversal of liver fibrosis by inhibition of selected ABC-transporters in hepatic stellate cells
- Leververvetting
- The role of the complement system in the development and progression of non-alcoholic fatty liver disease
- Use of inhibitors of glycolipid metabolism to treat NAFLD and NASH
- Niet Alcoholische Steatose Hepatitis (NASH)
- Cholesterol metabolism in Kuppfercells as a cause of liver inflammation in NASH
- The role of the intestinal farnesoid X-receptor FXR in cholestatic liver disease and NASH
- Use of inhibitors of glycolipid metabolism to treat NAFLD and NASH
- Primaire Biliaire Cirrose (PBC)
- Cholangiocyte dysfunction and the development of Primairy Biliary Cirrhosis
- Role of FGF19 in adaptive changes in the liver of patients with cholestatic liver disease
- The role of the intestinal farnesoid X-receptor FXR in cholestatic liver disease and NASH
- Vitamin A deficiency strongly aggravates liver damage during obstructive cholestasis: molecular mechanisms and implications for therapy
- Primaire Scleroserende Cholangitis (PSC)
- Role of FGF19 in adaptive changes in the liver of patients with cholestatic liver disease
- The role of the intestinal farnesoid X-receptor FXR in cholestatic liver disease and NASH
- Vitamin A deficiency strongly aggravates liver damage during obstructive cholestasis: molecular mechanisms and implications for therapy
- Progressieve Familiaire Intrahepatische Cholestase (PFIC)
- Generation and characterization of mouse models with a predisposition to cholestatic liver disease
Galblaas en galwegen
- Galstuwing
- Generation and characterization of mouse models with a predisposition to cholestatic liver disease
- Role of FGF19 in adaptive changes in the liver of patients with cholestatic liver disease
- The role of the intestinal farnesoid X-receptor FXR in cholestatic liver disease and NASH
- Vitamin A deficiency strongly aggravates liver damage during obstructive cholestasis: molecular mechanisms and implications for therapy
- Primaire Scleroserende Cholangitis (PSC)
- Role of FGF19 in adaptive changes in the liver of patients with cholestatic liver disease
- The role of the intestinal farnesoid X-receptor FXR in cholestatic liver disease and NASH
- Vitamin A deficiency strongly aggravates liver damage during obstructive cholestasis: molecular mechanisms and implications for therapy
- Progressieve Familiaire Intrahepatische Cholestase (PFIC)
- Generation and characterization of mouse models with a predisposition to cholestatic liver disease
Alvleesklier
- Alvleesklierkanker
- Identification of insulinoma-promoting genes on chromosome 9q
- Alvleesklierontsteking (acute)
- Small bowel ischemia in acute pancreatitis patients treated with probiotics and enteral feeding
- Transluminal ENdoscopic versus SurgIcal necrOsectomy in patients with infected pancreatic Necrosis: A randomised controlled multicenter trial (TENSION trial)
- Cystic Fibrosis (CF)
- Rescue of F508del-CFTR by proteasome inhibitors in cystic fibrosis mice and cystic fibrosis patients
Darm
- Campylobacter jejuni, infectie met
- Studies into gastro-enteritis and its sequelae caused by Campylobacter jejuni using organo-enzymatically synthesized lipo-oligosaccharide mimicks
- Colitis ulcerosa
- C-type lectin-like receptors: genotype, phenotype and carbohydrate-dependent microbial ligand-mediated stimulation of mucosal macrophages and dendritic cells in the pathogenesis of IBD
- Early immune responses in inflammatory bowel disease: studies in novel zebrafish colitis model
- Endoscopic trimodal imaging vs chromoendoscopy-guided confocal laser endomicroscopy as surveillance strategy for neoplasia in ulcerative colitis
- Enhancing the quality of life of patients with inflammatory bowel disease: A multi-center study investigating cognitive behavioural therapy
- Nicotinic agonists as a treatment for UC
- The role of secretory leukoprotease inhibitor (SLPI) in regulating anti-microbial responses in the gastro-intestinal tract
- Tissue factor in the pathophysiology of inflammatory bowel disease
- Function and phenotype of stromal cells in inflammatory bowel disease
- Immune regulation of remission during IBD
- Mesenchymal stem cell therapy for inflammatory bowel disease
- Dikkedarmkanker
- Prevention of the adenoma-carcinoma sequence: towards (1) biomarkers predictive of adenoma development and (2) understanding resistance to chemoprevention with sulindac
- Psychosocial impact of genetic risk assessment in newly diagnosed colorectal cancer patients and barriers for family communication
- Towards personalised medicine in the use of statins in colorectal cancer
- The role of Hedgehog signaling in colonic epithelial homeostasis
- Divertikels en diverticulitis
- A double-blind, placebo-controlled, multicenter, randomized clinical trial investigating the effectiveness of antibiotics in the treatment of uncomplicated acute diverticulitis (DIABOLA trial)
- Hereditair NonPolyposis Colorectaal Carcinoom (HNPCC)
- Modifiers of tumor development in Lynch syndrome
- Validation and implementation of a functional assay for the presymptomatic diagnosis of HNPCC
- Hirschsprung, ziekte van
- Genetically dissecting Hirschsprung disease by analyzing neural crest stem cells derived from colon biopsies of patients
- Ileus
- The cholinergic anti-inflammatory reflex in post-operative ileus
- PDS Prikkelbare darm syndroom
- The endocannabinoid system as potential therapeutic target in IBS
- Coeliakie
- Elucidation of the molecular mechanism by which gluten activates the innate immune system in coeliac disease patients
Overige
- Overig
- Functional abdominal pain (FAP) within the context of internalizing disorder in childhood: A randomized controlled cognitive- behavioural family intervention
- Identifying the gene(s) and pathogenesis of microvillus inclusion disease
- Impaired gastrointestinal motility is a major cause of reduced enterohepatic cycling of bile salts and may lead to impaired glucose and lipid metabolism
- Is c-Abl a potential target for therapy in Enteropathy Associated T-cell Lymphomas?
- Reduction of liver fibrosis by inhibition of insulin-like growth factor (IGF-1) binding protein-5
- Reversal of liver fibrosis by inhibition of selected ABC-transporters in hepatic stellate cells
- Role of the Lectin Complement Pathway in the outcome of orthotopic liver transplantation. A unique target to improve the outcome of liver transplantation
Vaak geraadpleegd
- A double-blind, placebo-controlled, multicenter, randomized clinical trial investigating the effectiveness of antibiotics in the treatment of uncomplicated acute diverticulitis (DIABOLA trial)
- Identification of insulinoma-promoting genes on chromosome 9q
- Role of the Lectin Complement Pathway in the outcome of orthotopic liver transplantation. A unique target to improve the outcome of liver transplantation
- Psychosocial impact of genetic risk assessment in newly diagnosed colorectal cancer patients and barriers for family communication
- Curbing c-Myc induced hepatocarcinogenesis through inhibition of PI-3-kinase